Exogenous Ketone Supplements May

Active on the faculty of the University of South Florida, Dominic D’Agostino focuses on research into ketone ester, muscle function, and related technologies. On the site KetoNutrition, Dominic D’Agostino explores various health aspects of ketone supplementation and the ketogenic diet (KD). One blog article on the site is titled “Aging, Age-Related Neurodegenerative Diseases, and Exogenous Ketone Supplements.”

Scientific observations dating back to the late 1930s indicate that a restricted-calorie diet leads to increased lifespan in animal models. Metabolic-associated pathways are closely linked with longevity, and ketogenic diets are a part of this matrix. An example involves rodent studies that indicate KD as helping to decrease midlife mortality in adult mice and increase their healthspan and longevity.

Many people find strict KD adherence, which limits dietary inputs such as carbs, challenging to maintain. An alternative therapeutic option for eliciting nutritional ketosis involves the use of exogenous ketone supplements (EKS). These generates increased ketosis, which modulates a variety of signaling pathways. These in turn can potentially improve symptoms related to multiple age-related clinical conditions. This is achieved both directly (through pathways mediated by β-Hydroxybutyric acid, or ketone salts) and indirectly (through reduced levels of insulin and glucose). The bottom line is that exogenous ketone supplements appear to play a significant role in addressing health issues associated with aging.

For more information, please visit KetoNutrition.org.

Ketogenic Diet as a Potential Way

Having led extensive research in area such as muscle function and ketone supplementation and technologies, Dominic D’Agostino is a University of South Florida associate professor. Also knowledgeable about ketone ester, Dominic D’Agostino presents findings at the website KetoNutrition. One article brings focus to the potential benefits offered by a ketogenic diet in fighting cancer.

Cancer cells rely on glucose as a primary fuel source and employ anaerobic glycolysis, an inefficient energy process, to survive and spread. In cases where the glucose supply that tumor cells rely on is restricted or limited, their growth is halted.

The ketogenic diet mimics fasting in that a low proportion of calories is derived from carbs, with most calories coming from fat. The body adjusts metabolism from glucose, which is normally the primary fuel source, to fat cells (or adipocytes), which generate ketone bodies. The metabolic state of ketosis is one of high ketone levels and low blood glucose levels, and this also serves to limit the available sugars that many types of tumorous cells rely on.

One use demonstrated in preclinical studies is a ketogenic diet serving as a sensitizing agent for radiation and chemotherapy, which increases the effectiveness of the cancer treatments in eliminating malignant cells while sparing normal cells.

For more information, please visit KetoNutrition.org