Addressing Fatty Liver and Metabolic Health Issues

Dominic D’Agostino is a University of South Florida professor who does research in areas such as ketone ester and supplementation technologies and muscle development. One topic featured on Dominic D’Agostino’s site, KetoNutrition.org, centers on fatty liver and metabolic health.

A vital metabolic organ, the liver is tasked with receiving and processing blood as it exits the stomach and intestines. This enables drugs and alcohol to be broken down into easily used forms. The liver also removes excess glucose from the circulatory system, storing it as glycogen, which is an energy storage unit. Additionally, the liver ensures that the blood has proper levels of amino acids and removes unwanted toxins, excreting bile.

Fatty liver occurs when excess fat builds up within the liver, which impairs the organ’s function. Non-alcoholic fatty liver disease (NAFLD) can involve inflammation that results in fibrosis, or scarring, and makes it more likely to develop liver cancer. Impacting a third of adults across the United States, NAFLD often occurs after the liver develops selective insulin resistance, with glucose lingering in the blood stream rather than being processed and triggering the liver to produce fat.

Reducing the buildup of fat in the liver is possible through a combination of exercise and a high-protein, low-carb diet. A low-carb, ketogenic diet has been shown to be effective in shifting liver fat metabolism in a positive manner, as well as improving gut microbiota and boosting levels of circulating folate, the latter of which powers beneficial forms of metabolism and gene expression within the liver.

In addition, a reduction of triglycerides and cholesterol intake can have a beneficial effect on one’s health. For those with elevated liver enzymes (revealed in blood tests), alcohol and fructose intake should be moderated. In addition, exogenous ketone supplements should be considered. Because there are no FDA-approved therapies for NAFLD, these steps are vital in addressing the serious issue of fatty liver, which can result in both cardiovascular and liver failure.

For more information, please visit KetoNutrition.org

The Cognitive Importance of Ketone Bodies

 Dominic D’Agostino is a renowned researcher with a keen interest in conducting ketone research, particularly on keto nutrition, ketone supplementation, and ketone ester. Also, in the course of his career, Dom D’Agostino has co-hosted several conferences on ketone bodies, ketone technologies and various other metabolic-based therapies centered around keto-nutrition.

Our cognitive capacity and resilience are important for not only daily consciousness and self-independence, but also relationships and brain health optimization. Cognitive skills are developed in early infancy as a component of maturing neurodevelopmental processes. Regrettably, retrograde alterations can happen during physiological aging. Various nutritional and dietary strategies provide viable cures for cognitive decline and preservation of cognitive capacity.

Following ketone production in the liver, or via ketone supplementation (e.g. KetoStart), peripheral tissues receive ketones for fuel and metabolic-associated signaling. The body typically employs ketones as an alternative fuel source, usually when glucose is scarce. With various techniques that partially imitate hunger and carbohydrate depletion, ketones can be purposefully elevated in the blood and biologically produced to boost physiological levels that can further enhance brain energy metabolism.

Consequently, ketone bodies support cognitive functions by contributing to the brain's bioenergetic capacity, and through signaling roles associated with suppression of neuroinflammation. Since metabolic bioenergy is one of the targets of drug models intended to treat cognitive diseases, the importance of ketone bodies to the brain cannot be over-emphasized.

Although glucose is the primary biofuel source that the body produces, aging cells or disease may impair the breakdown of glucose in the brain. Ketone bodies can effectively provide the fuel that might supplement the defective glycolytic metabolism, which consequently improves cognitive health and stops disease progression.

According to in vitro studies, ketones actively guard neurons against hypoglycemia-induced mortality and various environmental toxins too. This effect is possibly caused by both an increase in mitochondrial ATP production and a decrease in ROS production. The ketone body beta-hydroxybutyrate (BHB) can replace glucose in hypoglycemia situations, retaining metabolic activity, avoiding peroxidation, and impairing neuronal death. This has been demonstrated in both in vivo and in vitro research. This defense may be linked to the impact that ketone-induced autophagy has on cells and is one of the key features associated with the many cellular and molecular protective roles that nutritional or supplemental ketosis has on people using this longevity strategy. For more information on this topic and more see KetoNutrition.org website.

Getting Enough Omega-3 Fatty Acids on a Keto Diet

 Teaching at the University of South Florida, Dominic D’Agostino has a research focus on ketone supplementation and ketone ester, and the effect of a ketogenic diet on metabolism and muscle growth. One area that Dominic D’Agostino explored in a KetoNutrition article is how a keto diet affects one’s omega-3 fatty acid intake.

As a meat eater following a keto diet, the arithmetic is relatively simple: two or three servings of fatty fish each week should fulfill one’s docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) requirements. Both DHA and EPA are omega-3s that have been linked to a variety of positive health outcomes.

As a vegan, obtaining omega-3s is more challenging. Those who make the effort to eat walnuts, flax seeds, and chia on a regular basis may feel that that they have all the bases covered. Unfortunately, these foods are only rich in the omega-3 fatty acid alpha linolenic acid (ALA), which is a precursor to the even more vital DHA and EPA. While there is a slow enzymatic process by which the body does complete the conversion to the desirable omega-3, it would take large quantities of such foods to produce a sufficient quantity.

One plant-based solution is to eat microalgae in an accessible form such as the spirulina tablet ENERGYbits. Similar microalgae are consumed by fish such as sardines and salmon, who then store the DHA and EPA as fat. For more in depth discussion abotu this topic and other topics related to ketogenic nutrition be sure to check out KetoNutrition.org website and blog.

A Plant-Based Pathway for a Ketogenic Diet

 Dominic D’Agostino is a University of South Florida associate professor who undertakes clinical research in areas such as ketone ester and supplementation, and muscle performance. One of Dominic D’Agostino’s areas of expertise is a plant-based approach to a ketogenic diet, which is detailed on the KetoNutrition website.

While most people associate a keto lifestyle with abundant meat consumption, this is not necessarily the case. The classic strict 4:1 ketogenic diet has caloric intake of 90 percent fat, 6 to 10 percent protein, and 2 to 4 percent carbs. This makes significant vegetable consumption a challenge. However, today’s modified versions of the keto diet are more lenient, with 65 to 85 percent of daily calories derived from fat, 15 to 35 percent from protein, and as much as 10 percent from carbs.

A sustainable vegan keto diet is possible with this configuration. It starts with removing or severely limiting all legumes, grains, and fruit. Without the fat that meat and dairy provide, make healthy oils such as those from coconut, walnut, and avocado an integral part of your daily diet. At the same time, remove all root vegetables from the diet, such as beets or potatoes, as they are not fibrous and are typically high in carbohydrates. Once an ideal diet is in place, carefully track the macronutrient ratios (not calories) required for sustaining nutritional ketosis.

How Ketone Bodies Fuel Muscle Adaptation

 Instructing at the University of South Florida, Dominic D’Agostino is a professor who pursues basic science research and clinical applications of ketone ester supplementation, ketone salts and related ketone technologies. A particular area of interest for Dominic D’Agostino is muscle function and its pivotal role in augmenting performance and overall metabolic health. When a body goes into ketogenesis under carb-restricted dietary conditions, ketone bodies such as beta-hydroxybutyrate (BHB), acetoacetate (AcAc), and acetone are generated by the liver and provide a energetic reserve and important tissue signaling functions.

During exercise, the muscles no longer primarily rely on glycogen (high intensity workout) or lipids and muscle protein amino acids (low intensity workout) for generating the fuel adenosine triphosphate (ATP). Rather, ketone bodies are gradually employed by working muscles as fuel, with the capacity to oxidize the ketone bodies for energy increasing as muscle is trained. Part of being in a keto-adapted state is the increases levels of ketogenesis, ketone transport and tissue ketone utilization (ketolysis).

Beyond this muscle-fueling purpose, ketone bodies serve as signaling molecules for regulating the body’s gene expression and adaptive responses to energetic stress and exercise intervention. One study demonstrated that ketone BHB offers a shield against oxidative stress. It prevents the accumulation of intramuscular fat and decreases muscle wasting, while boosting oxidative metabolism as one ages. In tandem with this, BHB was shown to upregulate the genes associated with muscle atrophy and reduce anabolic gene expression. In this context the elevation of ketones helps to spare energy reserves. Ultimately, it is shown that the ketogenic diet has different effects on skeletal muscle that are partially explained by muscle fiber type, while the ketogenic diet can lead to a change in the fiber type ratio in the muscle itself. While currently the data is contradictory on the ketogenic diet’s benefits and adverse effects on muscle tissue, there is still room for discovery to be made in how the ketogenic diet impacts muscle metabolism in states outside of prolonged fasting and starvation. Based upon what we know about the anti-catabolic effects of ketones, and their multifunctional role during starvation, the benefits of being in ketosis appear to have the greatest effect during metabolic stress associated with disease states and exercise-induced stress. In this context the ketone-induced effects are protective and may confer a longevity advantage when it comes to longevity and long term preservation of muscle structure and function.

Continuous Glucose Monitors Enhance Education of Medical Students

 Teaching at the University of South Florida at the Morsani College of Medicine and performing research in ketogenic diet and ketone supplementation, Dominic D'Agostino possesses extensive knowledge on exogenous ketone supplementation and ketone technologies that help muscle performance and resilience. Dominic D'Agostino follows the latest findings in his field, including an American Journal of Lifestyle Medicine report on a pilot metabolic immersion program that employed continuous glucose monitors (CGMs) in medical students as part of a "metabolic immersion" program to enhance awareness and best practices within metabolic medicine and diabetes management.

The study involved 13 healthy students at Harvard Medical and Dental training on CGMs while being screened for underlying health issues. The students used the CGMs for 30 to 40 days while their dietary intake was tracked, in addition to a number of other variables that would help to assess the utility of CGMs for medical training.

Questionnaires revealed that participants felt the CGMs provided important insights into how the body reacts to food intake and aided with their medical education. In particular, CGMs made them more aware of how they could assist patients with diabetes battling elevated glucose levels. The CGM also encouraged them to alter their eating habits. Such devices, which encourage lifestyle modification and nutrition, may also inform the choices of those who opt for a low-glucose/ low carbohydrate ketogenic diet. For more information, please visit Levels Health and KetoNutrition.org.

New Research Links Ketogenic Diet to Gut Microbiome, Neurologic Health

 

An accomplished scientist and associate professor at the University of South Florida, Dr. Dominic D’Agostino researches ways of improving human neurology and physiology through the ketogenic diet. Dominic D’Agostino has broad knowledge of ketone esters, ketone supplementation, and ketone technologies. He shares his knowledge on KetoNutrition.org. One of his recent articles is on the gut-brain axis (GBA).

The gut-brain axis (GBA) refers to the physiological highway connecting the brain’s central nervous system (CNS) with the enteric nervous system (ENS) in the intestines. The ENS is responsible for body functions that do not require thinking about like digesting food, breathing, and circulating blood. The vagus nerve is the physiological highway between these two systems.

Information flow along the vagus nerve is two-way. The brain communicates its needs to the gut through the vagus nerve while the gut microbiome in the ENS produces key neurotransmitters that travel to the brain and eventually regulate neurologic, metabolic, and immune functions. A healthy gut microbiome, therefore, is essential to overall wellness.

The health of the gut microbiome is influenced by a number of things, key among them diet. Emerging research points to the benefits of a ketogenic diet to the gut microbiome and neurological health. Research on children with epilepsy has shown that a ketogenic diet improves regulation of immune factors central to controlling seizures. Additional research has linked the ketogenic diet to enhanced mental health. Specifically, when ketones become the brain’s primary source of energy, as is the case in a ketogenic diet, levels of the calming neurotransmitter GABA increase while those of the excitatory neurotransmitter glutamate fall. The diet further elevates adenosine levels, which also contributes to neurologic health.

Keto and Cancer - Understanding KMT

Dominic D’Agostino, PhD, is a research scientist investigating the science and application of the ketogenic diet and exogenous ketones, sometimes referred to more generally as "nutritional ketosis". The use of exogenous ketones in the form of ketone esters and ketone salt supplementation is also a significant part of his research efforts.. An associate professor at the University of South Florida, Morsani College of Medicine in Tampa, Dr. Dominic D’Agostino produces a KetoNutrition newsletter, where he covers topics such as application of the keto diet and ketogenic metabolic therapy (KMT).

Metabolic-based therapies, including KMT, shifts metabolic physiology and brain energy metabolism to manage verious disease processes and to strengthen resistance to illnesses. The application of KMT uses a well formulated keto diet as a base therapy, specialized supplements, and in some cases drugs. Published research and trials on clinicaltrials.gov show that many researchers are exploring how the ketogenic diet and KMT (additional things that enhance ketosis) can fight cancers that thrive on glucose and glutamine, including breast cancer.

Studies indicate that a healthy and well-balanced diet can reduce cancer risk, and this is primarily due to improving various metabolic biomarkers like blood glucose, insulin, triglycerides and reducing overall body weight.. In fact, proponents claim that alternative diets stimulate metabolism and boost the immune system to fight cancer. Specifically, diet therapy can enhance cancer-specific immune regulation through physiological changes.

Notably, there is growing evidence on how KMT affects cancer cells through pleiotropic effects. It works by reducing insulin secretion and glucose transport into tumor cells. At the same time, it increases fat burning effects and ketone body production, a metabolic fuel that nourishes healthy cells but has direct anti-cancer effects.. Together with glutamine targeting (EGCG and Theanine), emerging evidence demonstrates that KMT can target tumor cells and reduce inflammation without injuring surrounding healthy tissue. In addition, the ketone supplementation with ketone esters or exogenous ketone salts (KetoStart) can further enhance KMT by improving (lowering) the Glucose/Ketone Index (GKI). For more information on metabolic targeting of cancer with nutrition, including the science and application of ketone supplements, go to the Blog of KetoNutrition.org

Winning the Fight Against Neurogenerative

Since June of 2006, Dominic D’Agostino, PhD, has served as an associate professor at Tampa’s University of South Florida. In addition to his ketone research, Dr. Dominic D’Agostino supports the organization Winning the Fight. The nonprofit performs research and provides support for patients with neurodegenerative diseases and their loved ones.

Neurodegenerative diseases degrade the health and functioning of a patient’s central nervous system over time. Conditions of this type do not currently have cures, but treatments exist that can slow, or even stop, their progression.

Winning the Fight’s Deanna Protocol (DP) is a regimen of supplements that compensates for the lack of certain chemicals in ALS {Lou Gehrig’s Disease) patients’ nerve cells. When a nerve cell dies, it releases glutamate, a neurotransmitter that kills the cells around it, accelerating ALS’ progression. The DP Plan is an inexpensive way to extend nerve cells’ lifespans without the side effects of well-known ALS drugs. Patients can utilize the DP Plan by itself, or alongside other treatments.

To begin the DP Plan, patients register on Winning the Fight’s website. They then take a survey that evaluates the progression of their condition. Once approved, they not only gain access to the physical supplements, but also to an online community for patients and their loved ones with shared experiences.

For more information on Dr. D’Agostino and his research efforts, visit KetoNutrition.org and https://www.instagram.com/dominic.dagostino.kt.

Exogenous Ketone Supplements May

Active on the faculty of the University of South Florida, Dominic D’Agostino focuses on research into ketone ester, muscle function, and related technologies. On the site KetoNutrition, Dominic D’Agostino explores various health aspects of ketone supplementation and the ketogenic diet (KD). One blog article on the site is titled “Aging, Age-Related Neurodegenerative Diseases, and Exogenous Ketone Supplements.”

Scientific observations dating back to the late 1930s indicate that a restricted-calorie diet leads to increased lifespan in animal models. Metabolic-associated pathways are closely linked with longevity, and ketogenic diets are a part of this matrix. An example involves rodent studies that indicate KD as helping to decrease midlife mortality in adult mice and increase their healthspan and longevity.

Many people find strict KD adherence, which limits dietary inputs such as carbs, challenging to maintain. An alternative therapeutic option for eliciting nutritional ketosis involves the use of exogenous ketone supplements (EKS). These generates increased ketosis, which modulates a variety of signaling pathways. These in turn can potentially improve symptoms related to multiple age-related clinical conditions. This is achieved both directly (through pathways mediated by β-Hydroxybutyric acid, or ketone salts) and indirectly (through reduced levels of insulin and glucose). The bottom line is that exogenous ketone supplements appear to play a significant role in addressing health issues associated with aging.

For more information, please visit KetoNutrition.org.

Ketogenic Diet as a Potential Way

Having led extensive research in area such as muscle function and ketone supplementation and technologies, Dominic D’Agostino is a University of South Florida associate professor. Also knowledgeable about ketone ester, Dominic D’Agostino presents findings at the website KetoNutrition. One article brings focus to the potential benefits offered by a ketogenic diet in fighting cancer.

Cancer cells rely on glucose as a primary fuel source and employ anaerobic glycolysis, an inefficient energy process, to survive and spread. In cases where the glucose supply that tumor cells rely on is restricted or limited, their growth is halted.

The ketogenic diet mimics fasting in that a low proportion of calories is derived from carbs, with most calories coming from fat. The body adjusts metabolism from glucose, which is normally the primary fuel source, to fat cells (or adipocytes), which generate ketone bodies. The metabolic state of ketosis is one of high ketone levels and low blood glucose levels, and this also serves to limit the available sugars that many types of tumorous cells rely on.

One use demonstrated in preclinical studies is a ketogenic diet serving as a sensitizing agent for radiation and chemotherapy, which increases the effectiveness of the cancer treatments in eliminating malignant cells while sparing normal cells.

For more information, please visit KetoNutrition.org

Ketogenic Diets Come to the Fore for Health and Appetite Control

An associate professor at the University of South Florida Morsani College of Medicine, Dominic D’Agostino, PhD, has a focus on ketone research, supplementation, and emerging ketone technologies. Dominic D’Agostino’s ketone ester studies explore mechanisms by which KetoNutrition can fight cancer, preserve muscle, and contribute to overall metabolic wellness. 

Dr. D’Agostino was featured in a recent Men’s Health article, “Inside the Rise of Keto: How an Extreme Diet Went Mainstream,” that brings focus to a diet that strictly limits carbs, fruits, and vegetables. The common misconception is that the ketogenic diet is a high protein diet, but it is often capped at or below 100 grams daily (1 gram protein/kg) with up to 90 percent of calories coming from fat in the form of foods such as eggs, fish, steak, bacon, butter, nuts and coconut oil. The modified ketogenic diet has been gaining more popularity, even clinically, and it is characterized by more liberal amounts of protein that can be as high as 30% of calories. 

This dearth of carbohydrates, low to moderate protein, combined with abundant fat, results in the body entering a state of ketosis, in which fat and ketones, rather than glucose, is primarily burned for energy. Beneficial effects on health biomarkers are seen in blood pressure, blood glucose, triglyceride levels, HDL cholesterol and fasting insulin. Crucially, the diet reduces hunger, as fat and carbs ingested together trigger dopamine release, which provides the brain circuits with extra motivation to consume food. Additionally, the elevation of blood ketones helps to regulate the neurometabolic and neuropharmacological state of the brain towards homeostasis, which not only prevents cravings, but helps to improve moods and preserve a more balance psychological state.

Ketogenic Research Efforts at the University of South Florida

A former research scientist at the University of Medicine and Dentistry of New Jersey, Dominic D'Agostino serves as a traveling research scholar for the Florida Institute for Human and Machine Cognition (IHMC). Also an associate professor at the University of South Florida, Dominic D'Agostino has assisted with research for KetoNutrition, Ketone Technologies, and the development and testing of exogenous Ketone Supplementation (Ketone Esters).

In 2015, the Hyperbaric Biomedical Research Laboratory at the University of South Florida employed a unique combination of ketone supplementation and a ketogenic diet with hyperbaric oxygen therapy for cancer management. The study, undertaken on mice with advanced metastatic cancer, demonstrated that ketosis has beneficial effects against cancer cells, which cannot transform ketones into energy as healthy cells do. Further testing is being done on other cancer models to determine what types of cancer will be most responsive to this treatment. 

Ketosis is the metabolic process whereby the body obtains its energy from fatty acids rather than carbohydrates. In that process, the liver produces molecules known as ketones from the fatty acids. Ketones serve as an alternative fuel for the brain and have important signaling roles on gene expression and suppression (e.g. HDACI) of anti-inflammatory pathways (e.g. NLRP3). 

For the pre-clinical mouse study, researchers divided the mice into one group that received a typical diet high in carbohydrates and another group that received a modified ketogenic diet with ketone supplements alongside hyperbaric oxygen therapy. Those in the second group lived significantly longer than those in the control group and had reduced tumor burden. 

Since completing this initial research, the University of South Florida has continued to pursue research for treating cancer through therapeutic ketosis and ketone supplements. The university's researchers have also partnered with other researchers, including those at Moffitt Cancer Center, in preparing for clinical trials with humans. They collaborated on a rreview paper that was recently published in Seminars in Cancer Biology.

Starving cancer: Dominic D'Agostino at TEDxTampaBay